2 thoughts on “Why is the intestinal flora participating in the development of lupus erythematosus? How to understand?”
Ira
Lupus is an autoimmune disease characterized by chronic inflammation and multi -organ damage. Patients with lupus are reduced tolerance, and their own antibodies continue. The complex mechanism of autoimmune response in lupus lesions has not yet been fully clarified. In addition to some specific genetic factors and environmental triggers, the important role of the intestinal flora in regulating the host's immune system has gradually attracted the attention of scientists. However, the accurate description of the characteristics of the flora in patients with lupus and the in -depth understanding of its pathogenesis mechanism is still lacking. In this trial, Zhang's team recruited 117 lupus patients who did not receive treatment or antibiotic intervention within 3 months, and collected their feces and clinical information. At the same time, 115 healthy people with gender and age match as the control group. In addition, 52 patients who had relieved their condition after effective treatment (a significant decrease in disease activity scores) performed self -control before and after the study. All samples are detected by the Shotgun macroscopic group, and the classic macao group analysis method Humann2 is used for species and functional annotations. This analysis of species shows that the diversity of intestinal flora in patients with lupus erythematosus is significantly reduced, especially patients with lupus nephritis. The types and distribution of intestinal flora are significantly different from the control group (health crowd), and there are significant differences from before and after treatment. The six bacteria in the intestines of unbridden lupus patients have increased significantly, and they have decreased after treatment, including SP. ATCC BAA-442, Leptum, Atopobium Rimae, satellite, picillic bacteria and Fragilis. we also found that the function of the intestinal flora in patients with lupus patients is different from the control group, and the functional differences are more significant than the composition of species. Among the underaocal erythematosus, branches of amino acid synthesis, proofol degradation, and thiamine (vitamin B1) synthetic pathway have been significantly reduced before treatment; the LPS synthesis pathway is significantly up or down after treatment.
Lupus is an autoimmune disease characterized by chronic inflammation and multi -organ damage. Patients with lupus are reduced tolerance, and their own antibodies continue. The complex mechanism of autoimmune response in lupus lesions has not yet been fully clarified. In addition to some specific genetic factors and environmental triggers, the important role of the intestinal flora in regulating the host's immune system has gradually attracted the attention of scientists. However, the accurate description of the characteristics of the flora in patients with lupus and the in -depth understanding of its pathogenesis mechanism is still lacking.
In this trial, Zhang's team recruited 117 lupus patients who did not receive treatment or antibiotic intervention within 3 months, and collected their feces and clinical information. At the same time, 115 healthy people with gender and age match as the control group. In addition, 52 patients who had relieved their condition after effective treatment (a significant decrease in disease activity scores) performed self -control before and after the study. All samples are detected by the Shotgun macroscopic group, and the classic macao group analysis method Humann2 is used for species and functional annotations.
This analysis of species shows that the diversity of intestinal flora in patients with lupus erythematosus is significantly reduced, especially patients with lupus nephritis. The types and distribution of intestinal flora are significantly different from the control group (health crowd), and there are significant differences from before and after treatment. The six bacteria in the intestines of unbridden lupus patients have increased significantly, and they have decreased after treatment, including SP. ATCC BAA-442, Leptum, Atopobium Rimae, satellite, picillic bacteria and Fragilis.
we also found that the function of the intestinal flora in patients with lupus patients is different from the control group, and the functional differences are more significant than the composition of species. Among the underaocal erythematosus, branches of amino acid synthesis, proofol degradation, and thiamine (vitamin B1) synthetic pathway have been significantly reduced before treatment; the LPS synthesis pathway is significantly up or down after treatment.
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